异生菌化合物对孕前的影响以及潜在的机制
Miaoliang Wu1,2, Fuhui Yan1,2, Qian Liu2
1The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China.
Toxics
|June 27, 2023
概括
环境中的毒素,特别是内分泌干扰剂,可能会引发妊娠前 (PE),这是一个严重的妊娠状况. 本综述探讨了外源化学物质和PE之间的联系,旨在防止对母亲和胎儿的不良结果.
科学领域:
- 环境健康 环境健康
- 产科 产科 产科 产科 产科
- 毒理学 毒理学 毒理学
背景情况:
- 孕前 (PE) 是一种妊娠并发症,20周后的特征是新发高血压和白色素尿或末端器官损伤.
- 孕前期显著增加了孕产妇和胎儿的发病率和死亡率,造成了相当大的社会负担.
- 新出现的证据表明,环境中的异生菌化合物,特别是内分泌干扰物,可能在PE发展中发挥作用,尽管机制尚不清楚.
研究的目的:
- 审查外源化学物质在诱导子宫前中的作用.
- 阐明环境因素导致PE的潜在机制.
- 为改善预防策略提供先孕的环境病因学的前景.
主要方法:
- 对调查环境化学物质暴露与产前之间的关联的研究进行文献综述.
- 对拟议的生物途径的分析,将异生菌与PE病原体联系起来.
- 综合目前对PE环境病因学的理解.
主要成果:
- 对某些异生菌,包括内分泌干扰剂的环境暴露越来越多地与孕前的发展有关.
- 潜在的机制包括胎盘功能障碍,螺旋动脉改造受损和氧化应激.
- 了解这些途径对于识别环境风险因素至关重要.
结论:
- 外源性化学物质暴露是产前病病因学的重要,但尚未研究的环境因素.
- 进一步研究化学诱导PE的机制对于制定有效的预防措施至关重要.
- 解决环境因素可能会提供新的策略,以减少先孕的全球负担.
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