选择的东开普省农村医院的结核病患者的治疗结果和相关因素:一项双向研究
Lindiwe M Faye1, Mojisola C Hosu1, Joshua Iruedo2
1Department of Laboratory Medicine and Pathology, Walter Sisulu University and National Health Laboratory Services (NHLS), Private Bag X5117, Mthatha 5099, South Africa.
Tropical medicine and infectious disease
|June 27, 2023
概括
在南非农村地区结核病 (TB) 治疗的成功率为65.8%,低于世卫组织标准,HIV联合感染对结果产生了负面影响. 加强结核病监测和控制对于改善患者结果至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 评估结核病 (TB) 治疗结果对于结核病控制计划的有效性至关重要.
- 终结结核病战略要求对治疗结果进行有效评估,以实现全球目标.
- 南非东开普省的农村地区在结核病管理方面面临着挑战.
研究的目的:
- 在南非东开普省农村地区调查结核病治疗结果.
- 确定与结核病治疗成功和失败相关的因素.
- 评估HIV同时感染对结核病治疗结果的影响.
主要方法:
- 从457名耐药结核病 (DR-TB) 患者的临床记录进行了回顾性分析.
- 101名患者的前性随访.
- 使用Stata 17.0进行统计分析,计算赔率比率和95%置信区间.
主要成果:
- 整体治疗成功率为65.8%,低于世卫组织的值.
- 与HIV阴性患者相比,HIV阳性患者的治疗成功率为61.2%.
- 吸烟者经历了更长的治疗时间;艾滋病毒/结核病联合感染与不良结果和男性占优势有关.
结论:
- 在这个南非农村环境中,结核病治疗成功率低于最佳水平.
- 艾滋病毒和结核病的同时感染对有效的结核病管理构成重大挑战.
- 建议加强结核病监测,控制策略和患者随访.
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