应该使用直接口服抗凝剂来治疗蛋白C或S缺乏吗?
Kiya K Bennett1, Nicholas C Schwier
1Kiya K. Bennett is an assistant professor in the Department of Pharmacy: Clinical and Administrative Sciences in the University of Oklahoma Health Sciences Center's College of Pharmacy in Oklahoma City, and a clinical pharmacy specialist in internal medicine at the University of Oklahoma Medical Center. At the time this article was written, Nicholas C. Schwier was an associate professor in the Department of Pharmacy: Clinical and Administrative Sciences at the University of Oklahoma and a clinical pharmacy specialist in cardiology at the University of Oklahoma Medical Center. He now is assistant dean of experiential education and a clinical associate professor in the School of Pharmacy and Pharmaceutical Sciences at Binghamton University in Johnson City, N.Y. Dr. Schwier discloses that he has received honoraria from and serves on the speaker's bureau for Kiniksa Pharmaceuticals. The authors have disclosed no other potential conflicts of interest, financial or otherwise.
直接口服抗凝剂 (DOAC) 在蛋白质C或S缺乏症中的使用尚未得到充分研究. 目前的数据不一致,使得传统的抗凝剂如华法林和肝素对于血栓友爱患者来说是可取的.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 主要的血栓,包括蛋白质C和S缺乏,构成血栓形成的重大风险.
- 直接口服抗凝剂 (DOACs) 越来越多地用于抗凝,但它们在特定的血栓性状态中的安全性和有效性不太清楚.
研究的目的:
- 审查目前关于DOACs在被诊断患有主要血栓形成症,特别是蛋白C或S缺乏症的患者中的使用证据.
- 识别这些患者群体的抗凝血策略的知识缺口,并指导临床实践.
主要方法:
- 进行了文献搜索,以确定在患有蛋白C或S缺乏症的患者中评估DOAC的研究.
- 分析了DOAC类型,剂量,患者特征和临床结果的数据异质性.
主要成果:
- 现有的关于蛋白质C或S缺乏的DOAC的研究是有限的和异质的.
- 使用的DOAC,剂量方案,患者人口统计和结果测量的变化使数据的解释变得复杂.
结论:
- 目前关于蛋白质C或S缺乏症的DOACs的数据不足以制定明确的指导方针.
- 维生素K对抗剂和低分子量肝素仍然是这些患者首选的抗凝剂,等待进一步的研究.
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