肌肉密度和面积与冠状动脉斑块和身体功能的关联
Kristine M Erlandson1, Triin Umbleja2, Michael T Lu3
1Division of Infectious Diseases, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO.
Journal of acquired immune deficiency syndromes (1999)
|June 27, 2023
概括
艾滋病毒感染者 (PWH) 具有较高的副脊髓肌肉密度与较少的冠状动脉疾病有关. 较大的肌肉面积与更好的身体功能有关,这表明肌肉质量会影响PWH患者的健康.
科学领域:
- 老年学是一门学科.
- 艾滋病毒 医学 艾滋病毒 医学
- 心血管疾病 心血管疾病
背景情况:
- 骨肌质量和质量对于身体功能至关重要,特别是在衰老时.
- 保持肌肉健康对于艾滋病毒感染者至关重要,他们可能面临加速衰老和心血管风险增加.
- REPRIEVE试验提供了一个独特的数据集,用于探索PWH的肌肉健康.
研究的目的:
- 为了研究副脊髓肌肉密度和面积与PWH中的心脏和身体功能结果之间的关联.
- 利用随机试验预防艾滋病毒血管事件 (REPRIEVE) 的基线数据.
主要方法:
- 从REPRIEVE试验的基线数据的横截面分析.
- 使用非对比计算断层扫描评估胸部副脊髓肌肉密度 (霍恩斯菲尔德单位) 和面积 (厘米2).
- 冠状动脉计算机断层扫描用于评估心脏结果.
主要成果:
- 较大的副脊髓肌肉密度与较低的冠状动脉斑块和冠状动脉的患病率有关.
- 肌肉区域与冠状动脉斑块测量没有显著的关联.
- 增加的肌肉面积,但不是密度,与更好的身体功能测试表现相关 (短的身体性能电池,握力).
结论:
- 在PWH中,较高的副脊髓肌肉密度与降低冠状动脉疾病患病率有关.
- 较大的副脊髓肌肉区域与改善的体力表现有关.
- 在REPRIEVE中的纵向分析将检查肌肉密度和区域的变化如何随着时间的推移影响心血管疾病和身体功能.
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