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Updated: Jul 25, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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循环素依赖性激酶4和6 (CDK4/6) 抑制剂:现有和新兴的差异

Stephen Johnston1, Anna Emde2, Carlos Barrios3

  • 1Breast Unit, The Royal Marsden NHS Foundation Trust, London, UK.

JNCI cancer spectrum
|June 27, 2023
PubMed
概括

循环素依赖性激酶4和6 (CDK4/6) 抑制剂改善了晚期乳腺癌的存活率. 然而,它们在早期疾病中的有效性有所不同,这促使人们对潜在的机制和耐药性的研究.

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