肺结节恶性瘤的循环蛋白质组
Elham Khodayari Moez1, Matthew T Warkentin1,2, Yonathan Brhane1
1Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
Journal of the National Cancer Institute
|June 27, 2023
概括
循环蛋白标记物在查期间发现的恶性和良性肺结节的区分方面表现有前途. 在临床使用之前需要进一步验证.
科学领域:
- 发现生物标志物的发现.
- 肺结节的特征 肺结节的特征
- 肺癌查 肺癌查 肺癌查
背景情况:
- 在肺癌查中,区分不确定的肺结节是一个挑战.
- 低剂量计算机断层扫描 (LDCT) 查在全球变得越来越普遍.
- 需要可靠的方法来区分查期间检测到的恶性和良性结节.
研究的目的:
- 研究循环蛋白标记物,以区分恶性和良性肺结节.
- 开发蛋白质负荷评分 (PBSs) 以评估结节恶性和迫在眉的瘤.
- 在LDCT查研究中评估PBS和结节恶性瘤之间的关联.
主要方法:
- 在4个LDCT查研究中,从1253名参与者的预诊断血液样本中测试了1078种蛋白质标记物.
- 采用嵌套病例控制设计和近距离扩展试验来测量蛋白质.
- 使用多变量后勤回归,随机森林和处罚回归进行数据分析,估计PBSs.
主要成果:
- 确定了36个信息循环蛋白标记物,形成了一个生物网络.
- 十个标志物对预测1年内肺癌具有特别重要的意义.
- 增加的PBS与结恶性和迫在眉的瘤的更高几率显著相关,即使在LungRADS类别4结中.
结论:
- 循环蛋白标记物可以帮助区分恶性和良性肺结节.
- 蛋白质负担得分显示了风险分层的可能性.
- 在临床应用之前,需要在新队列中进行独立验证.
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