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Updated: Jul 25, 2025

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IL-7受体信号驱动人类B细胞原始体的分化和扩张

Fabian M P Kaiser1, Iga Janowska2,3, Roberta Menafra4

  • 1Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Blood
|June 27, 2023
PubMed
概括

介素-7受体α (IL-7Rα) 信号传递对人类B细胞发育至关重要,驱动早期前代细胞扩张和B淋巴细胞命运. 这一发现与小鼠模型形成鲜明对比,影响了对免疫缺陷和白血病的理解.

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