在嵌套原细胞群体中自主集成
Zhuping Yin1, Ning Gao1,2, Can Xu1
1Centre for Protolife Research, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Journal of the American Chemical Society
|June 27, 2023
概括
研究人员创造了自我组织的,嵌套的原细胞群体, 这些人造细胞群体表现出协调的功能,可以根据需要稳定或分解.
科学领域:
- 仿生材料科学
- 合成生物学
- 软物质物理
背景情况:
- 模型原细胞提供了一个理解生命起源和构建人工细胞系统的平台.
- 在合成细胞中实现协调的行为和更高层次的组织仍然是一个重大挑战.
研究的目的:
- 开发一个半自主机制来创建嵌套的共生原细胞群体.
- 探索人工细胞系统的自我组织和功能整合.
- 设计具有复杂结构和功能性质的可重新配置的细胞仿真材料.
主要方法:
- 利用一种类似于内共生的途径,在酸盐/丝蛋白共囊中捕获蛋白质体.
- 由酶活性 (尿素酶/葡萄糖氧化酶) 介导的同囊体的形态变化.
- 实现燃料驱动的自动驾驶能力和酶介导的结构稳定矩阵强化.
主要成果:
- 成功形成了具有综合催化活性的原细胞的离散嵌套群体.
- 展示了这些社区的选择性解体.
- 通过二超分子组合和胺-酸盐交叉链接实现结构稳定.
- 通过内部化粉水溶酶证明了自动驾驶能力的调节.
结论:
- 这项研究提出了一种新型的半自主机制,用于构建共生,类似细胞的嵌套社区.
- 这项工作促进了人工多细胞性和可重新配置的细胞模拟材料的发展.
- 这些发现为创建具有新兴结构,功能和组织复杂性的材料开辟了道路.
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