慢性炎症性去髓化多基原蛋白神经病在没有系统活动的全身性红斑狼患者中
Omar-Javier Calixto1,2, Santiago Poveda3, Maria Alejandra Meneses-Toro1,2
1Clinical Immunology Group, Department of Rheumatology and Immunology, Hospital Militar Central, Bogotá, Colombia.
Lupus
|June 27, 2023
概括
慢性炎症性脱髓化多基原蛋白神经病变 (CIDP) 是系统性红斑狼 (SLE) 中的一种罕见的外周神经病变. 这一案例突显了SLE中CIDP在免疫抑制疗法 (包括环胺) 的成功治疗.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病.
- 慢性炎症性脱髓化多基原蛋白神经病变 (CIDP) 是一种罕见的外围神经病变的亚型.
- 在SLE患者中,CIDP特别不常见,仅发生在0.2%的病例中.
研究的目的:
- 报告一个出现CIDP的SLE病例.
- 为了描述这种罕见疾病的成功治疗.
主要方法:
- 通过使用欧洲神经学会联合会/外围神经学会标准确认了CIDP的诊断.
- 使用电子诊断测试来识别活跃的运动和感官脱髓性多神经病变.
- 治疗包括静脉注射免疫球蛋白,高剂量类固醇和6个月的静脉注射环胺.
主要成果:
- 这位患者出现了双边,渐进的,上升的感觉和运动神经病变.
- 通过免疫抑制疗法 (包括环胺) 成功治疗,导致临床改善.
- 在整个治疗期间,全身性红斑狼活动保持缓解状态.
结论:
- CIDP是一种罕见但可治疗的SLE表现.
- 当初始治疗不足时,免疫抑制疗法,如环胺,至关重要.
- 这种表现值得在风湿病学实践中考虑.
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