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在GW182/TNRC6上,多个RNA抑制途径的融合

Thomas Welte1, Alison Goulois2, Michael B Stadler3

  • 1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; Department of Medicine IV, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Molecular cell
|June 27, 2023
PubMed
概括

RNA结合蛋白TRIM71与TNRC6/GW182相互作用,使目标信使RNA (mRNA) 保持沉默. 这种相互作用揭示了一个共享的microRNA-like沉默活动跨多个路径,由TNRC6作为一个中央枢纽调节.

关键词:
AGO1 AGO1 的时间.GW182 GW182 的时间在LIN4141中,我们可以看到在TNRC6中,在 TRIM71 中,在UPF1中,它是UPF1.遗传性脑水症是先天性的.这是一个小RNARNA.转录后的基因调节.干细胞是一种干细胞.

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