鼻高频振荡通风与新生儿同步鼻间歇性正压通风之间的再输管率:一项并行随机对照试验
Manapat Phatigomet1, Anucha Thatrimontrichai1, Gunlawadee Maneenil1
1Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
鼻高频振荡通风 (nHFOV) 和同步鼻间歇性正压通风 (sNIPPV) 显示,新生儿在输出管后的再输入管率相似. 这项研究发现,这两种非侵入性通风方法在预防呼吸支功能衰竭方面没有显著差异.
科学领域:
- 新生儿的呼吸系统支持.
- 非侵入性通风技术的使用.
- 管术后的护理
背景情况:
- 鼻高频振荡通风 (nHFOV) 和同步鼻间歇性正压通风 (sNIPPV) 是新生儿的新兴非侵入性通风模式.
- 在新生儿护理方面,术后输管失败和重新输管仍然是重大挑战,特别是对于早产婴儿.
研究的目的:
- 为了比较nHFOV与sNIPPV在预防新生儿输卵后失败或重新输卵的疗效.
- 评估哪种非侵入性通风模式在输出管后为新生儿提供了更好的结果.
主要方法:
- 一项开放标签,并行随机研究与133名新生儿 (67名nHFOV,66名sNIPPV) 进行.
- 主要结局是,在脱后7天内重新灌输的比率.
- 亚组分析包括早产和非常早产新生儿.
主要成果:
- 在nHFOV (7%) 和sNIPPV (6%) 组 (p=0.99) 之间,在7天内重新灌输率没有显著差异.
- 在早产和非常早产子组中观察到类似的非显著的再灌输率.
- 不良事件包括在nHFOV的新生儿中发生的肺介质,在sNIPPV的新生儿中发生的肺出血.
结论:
- 无论是nHFOV还是sNIPPV,都没有在新生儿输卵术后7天内防止重新输卵方面表现出明显的优势.
- 这项研究表明,这两种非侵入性通风策略在该患者群体中的有效性相似.
- 可能需要进一步的研究来探索长期结果或特定的子群体.
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