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标准,集群和急性过敏免疫疗法构建协议的比较

Michael C Lee¹, Leah B Puglisi², John M Kelso¹

¹Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, Calif.

The journal of allergy and clinical immunology. In practice

|June 27, 2023

概括

对过敏免疫疗法 (AIT) 的集群协议提供更快的维护剂量,类似于急诊协议,但不需要预处理,并具有相似的安全性. 这使得集群免疫疗法成为寻求更快缓解症状的患者的实用替代方案.

科学领域:

免疫学免疫学免疫学
过敏学过敏学
临床医学临床医学

背景情况:

过敏免疫疗法 (AIT) 使用标准,集群或冲击剂量升级协议.
虽然集群和冲动协议加速达到维持剂量,但直接比较是有限的.

研究的目的:

为了比较标准,集群和急诊AIT协议之间的维护剂量和不良反应率的时间.
评估不同AIT剂量升级策略的有效性和安全性.

主要方法:

一项回顾性观察性研究分析了237名接受AIT的患者.
患者被分为标准,集群或急诊协议.
数据包括人口统计,维护时间,不良反应和AIT配方;急诊方案患者接受了额外的前期治疗.

主要成果:

冲击 (16.50周) 和集群 (19.33周) 协议的维持速度比标准协议 (31.09周) 快 (P < .001).
在集群和冲击协议之间没有发现维护时间的显著差异 (P = .322).
系统反应率在标准 (9.76%),集群 (9.84%) 和急诊 (14.86%) 协议中是相似的 (P = .526),尽管急诊协议的前期治疗.

结论:

集群AIT协议可以在与紧急协议相比的时间范围内实现维护剂量.
集群协议表现出类似的系统反应率,以加快协议,而不需要额外的预处理.
集群协议为加快AIT维护剂量提供了一种安全有效的替代方案.

关键词:

不良反应不良反应过敏免疫疗法免疫治疗这是一个Buildup.集群集群是一个集群集群.赶紧赶紧赶紧赶紧赶紧

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