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Updated: Aug 16, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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在基于细胞的查中发现的新型β-glucocerebrosidase chaperone化合物减少了iPS衍生的神经元细胞中病理积累的葡萄糖氨酸

Yusuke Naito1, Sou Sakamoto1, Takuto Kojima1

  • 1Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Japan.

SLAS discovery : advancing life sciences R & D
|June 27, 2023
PubMed
概括

研究人员确定了新的小分子化合物,它们作为药理伴侣来增强β-葡萄糖脑酶 (GCase) 活性. 这些化合物有望通过减少大脑中有毒脂质积累来治疗神经学氏病.

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Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

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Author Spotlight: Insight Into Advances in Prion Diseases Research

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相关概念视频

Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...