长期的实验性睡眠障碍会影响健康人群的炎症解决途径
Larissa C Engert1, Janet M Mullington1, Monika Haack1
1Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Brain, behavior, and immunity
|June 27, 2023
概括
实验性睡眠障碍显著降低了专门的亲解决媒介 (SPMs) 的调节,特别是D系列的解决药物,影响睡眠恢复后很长时间的炎症解决. 这表明睡眠不足与免疫相关疾病之间存在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 睡眠医学 睡眠医学
- 生物化学 生物化学
背景情况:
- 睡眠障碍与免疫病理学和疾病风险增加有关.
- 低级系统性炎症与睡眠问题有关.
- 睡眠障碍可能会影响特殊的促溶解媒介 (SPMs),对炎症溶解至关重要.
研究的目的:
- 研究长期实验性睡眠障碍 (ESD) 对由omega-3脂肪酸衍生的D和E系列溶解剂的影响.
- 为了确定睡眠障碍是否会影响身体的自然炎症解决过程.
主要方法:
- 24名健康参与者接受了两项为期19天的方案:实验性睡眠障碍 (ESD) 和对照.
- ESD涉及重复睡眠中断的夜晚,随后是恢复睡眠.
- 用液体染色学-并联质谱法 (LC-MS/MS) 测量了D和E系列溶解素的等离子水平.
主要成果:
- 17-HDHA (D系列前体) 和18-HEPE (E系列前体) 在ESD下调,并在恢复睡眠后保持低水平.
- RvD3,RvD4和RvD5被ESD显著下调,具有持久的影响.
- 在ESD中,RvD1升高,RvD2表现出复杂的变化;在RvD2和RvD4.4中注意到性别差异效应.
结论:
- 实验性睡眠障碍极大地降低了SPM的调节,特别是D系列的溶解素,在睡眠恢复后,其影响仍然存在.
- 睡眠障碍会干扰活性炎症的解决,可能导致免疫病理和疾病.
- 针对炎症解消途径的干预措施可以减轻与睡眠障碍相关的疾病风险.
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