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在实验动物模型中通过mRNA疫苗接种诱导的印记免疫的影响

Shigeru Fujita^1,2, Keiya Uriu^1,2, Lin Pan^1,3

¹Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

The Journal of infectious diseases

|June 27, 2023

概括

祖先的SARS-CoV-2疫苗可能会限制对Omicron亚型的免疫力,例如BQ.1.1和XBB.1. 仓鼠研究表明,印记免疫可能会降低针对这些新菌株的疫苗有效性.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

新出现的SARS-CoV-2 Omicron亚型 (例如,BQ.1.1,XBB.1) 引发了人们对祖先疫苗疗效的担忧.
"印记免疫"的概念假设,先前接触原始SARS-CoV-2菌株可能会损害对新变种的反应.

研究的目的:

为了调查是否与祖先的SARS-CoV-2mRNA疫苗的疫苗接种诱导"印记免疫"对Omicron亚型BQ.1.1和XBB.1在一个仓鼠模型.

主要方法:

仓鼠接受了3剂量mRNA-脂质纳米颗粒疫苗方案.
在接种疫苗后,仓鼠受到SARS-CoV-2 Omicron亚型BQ.1.1和XBB.1.的挑战.
在突破性感染后评估了幽默免疫力.

主要成果:

自然感染SARS-CoV-2诱导强大的抗病毒免疫力.
在接种疫苗的仓鼠中,BQ.1.1和XBB.1亚变体的突破性感染只导致弱性免疫反应.
这些发现支持印记免疫的假设.

结论:

用祖先的SARS-CoV-2mRNA疫苗接种疫苗可能会导致印记免疫力,可能会减少对新出现的Omicron亚变体的保护性反应.
需要进一步的研究来理解和潜在地克服印记免疫力,以改善针对像SARS-CoV-2这样快速演变的病毒的疫苗策略.

关键词:

这就是SARS-CoV-2病毒.被印记的免疫力这是mRNA疫苗.奥米克朗病毒是什么?

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