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萨尔科佩尼亚和贫血的结合预测,在患有扩散大B细胞淋巴瘤的老年患者中,结果会更差
Pi-Han Liao1,2, Yi-Hsuan Chuang3, Fu-Shine Yang4
1Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.
In vivo (Athens, Greece)
|June 27, 2023
概括
在患有扩散性大B细胞淋巴瘤 (DLBCL) 的老年患者中,低骨肌指数 (SMI) 和贫血与不良结果有关. 结合SMI,血红蛋白和乳酸脱酶的新得分可能会提高预后准确性.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 放射学 放射学是一门学科.
背景情况:
- 麻症和贫血与扩散型大B细胞淋巴瘤 (DLBCL) 的不良结果和增加的化疗副作用有关,特别是在老年患者中.
- 癌症中的贫血可能源于疾病和炎症,可能与肌肉质量损失和更糟糕的预后相关.
研究的目的:
- 调查DLBCL患者在第三腰椎 (L3) 和血红蛋白 (Hb) 水平的骨肌指数 (SMI) 之间的关联.
- 评估L3-SMI和Hb对DLBCL结果的预测值.
主要方法:
- 包括新诊断的DLBCL接受免疫化疗的老年患者 (≥70岁).
- 通过计算机断层扫描测量了性别特定的L3-SMI,并记录了治疗前的Hb水平.
- 使用卡普兰-梅尔和考克斯回归模型分析了生存率.
主要成果:
- 在贫血和低L3-SMI之间发现了相关性.
- 低L3-SMI和贫血 (Hb <10.5 g/l) 都预测了不良的无进展和整体存活率.
- 提出了一个新的预后得分,包括L3-SMI,Hb和乳酸脱酶,独立于国际预后指数.
结论:
- 麻症和贫血是老年DLBCL患者的重要因素.
- 结合L3-SMI,Hb和乳酸脱酶的新得分为DLBCL患者提供了额外的预后价值.
- 这一分数可以帮助治疗决策和患者管理.
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