创建一个以证据为基础的经济模型,用于在医院环境中预填充的亲肠道药物输送
Job F H Eijsink1, Mia Weiss2, Ashley Taneja3,4
1Isala klinieken and Department of Health Sciences, University of Groningen, Zwolle, The Netherlands.
概括
预填注射器 (PFS) 可以大大节省成本,并减少医院的准备时间. 从瓶子切换到PFS可以减少可预防的药物不良事件和药物浪费,提高整体效率.
科学领域:
- 医疗保健经济学 医疗经济学
- 制药科学 制药科学
- 临床药房 临床药房
背景情况:
- 预填注射器 (PFS) 具有潜在的临床和经济效益,相比于传统的瓶子和片药物输送.
- 对于采用PFS的现有经济模式往往是药物特定的,并且在不同的医疗保健环境和国家缺乏通用性.
研究的目的:
- 开发一个全面和可通用的经济模型来评估从瓶子转向PFS的影响.
- 通过案例研究来证明该模型的实用性,突出说明小瓶到PFS过渡的关键特征.
主要方法:
- 创建了一个经济模型来估计减少可预防的药物不良事件 (pADEs),准备时间,未使用的药物和供应成本的益处.
- 模型参考值来源于同行评审的文献,用户可以为部门,药物和剂量配置输入.
- 介绍了两项案例研究:英格兰心脏病重症监护室的阿特罗平和法国COVID-19重症监护室的埃弗德林.
主要成果:
- 氨酸案例研究预计每年节省34,829英,而氨酸案例研究预计每年节省104,570.0欧元.
- 每年的药物准备时间减少了371小时的阿特罗平和234小时的丁氨酸.
- 节约归因于减少pADEs,未使用的药物,药物成本和供应费用.
结论:
- 开发的模型为医院提供了一个可定制的框架,以评估采用PFS的临床和经济价值.
- 尽管每剂量成本可能更高,但采用PFS可以带来净预算节省和减少药物准备时间.
- 该研究强调了PFS在尽量减少药物浪费和通过减少pADEs提高患者安全方面的重要性.
相关概念视频
One-Compartment Open Model for IV Bolus Administration: General Considerations
254
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
254
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
105
Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
105
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
349
The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
349
Two-Compartment Open Model: IV Infusion
278
A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
278
Drug Delivery: Parenteral Route
642
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
642
Two-Compartment Open Model: IV Bolus Administration
585
The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
The disparity between drug input and the sum of drug transfer rates between...
585


