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Updated: Jul 25, 2025

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
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内CD8+CD20+ T细胞在初级进展性多发性硬化症中

Marina Rode von Essen1, Jacob Talbot2, Rikke Holm Holm Hansen2

  • 1From the Danish Multiple Sclerosis Center (M.R.E., J.T., R.H.H.H., H.H.C., F.S.), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup; Danish Research Centre for Magnetic Resonance (H.L., H.R.S.), Copenhagen University Hospital - Amager and Hvidovre; Department of Clinical Medicine (H.R.S.), University of Copenhagen; and Department of Neurology (H.R.S.), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark. marina.rode.von.essen@regionh.dk.

Neurology(R) neuroimmunology & neuroinflammation
|June 27, 2023
PubMed
概括

内CD8+CD20+T细胞与初级渐进性多发性硬化症 (PPMS) 中的白质损伤和胸膜缩有关. 丁甲基烟酸没有影响脑脊液 (CSF) 中的这些T细胞.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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