母亲暴露于童年虐待和不良出生结果
Lauren S Keenan-Devlin1,2,3, Ann E B Borders1,2,3,4, Alexa Freedman1,2,5,6
1, Evanston, IL, USA.
Scientific reports
|June 27, 2023
概括
母亲童年虐待 (CM) 显著增加了怀孕年龄小的出生 (SGA) 的风险. 每种额外的CM暴露形式都会增加SGA风险,强调早期逆境的代际影响.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 发展心理学 发展心理学
背景情况:
- 童年虐待 (CM) 与不利的健康结果有关.
- 怀孕前CM对怀孕和分娩结果的影响需要进一步调查.
- 了解CM对怀孕的影响对于母亲和婴儿健康至关重要.
研究的目的:
- 评估母体CM暴露与怀孕年龄较小的分娩 (SGA) 和早产 (PTB) 之间的关联.
- 检查CM相关的健康和行为后果是否适度或调解这些关联.
- 调查童年逆境对出生结果的代际影响.
主要方法:
- 对744名孕妇进行的前性队列研究 (母亲压力测量 - MOMS研究).
- 使用童年创伤问卷 (CTQ) 评估CM.
- 使用多变量逻辑回归分析的CM,后果 (肥胖,抑郁,高血压,物质使用) 和出生结果 (SGA,PTB) 之间的关联.
主要成果:
- 32%的参与者报告了母亲的CM暴露.
- 接触CM与SGA出生风险增加61%有关.
- 每种额外的CM暴露形式都会使SGA风险增加27% (aOR 1.27).
- 在CM和PTB之间没有发现显著的关联.
- 高血压疾病与CM和SGA有关,但没有调解CM-SGA关联.
结论:
- 母亲的CM暴露与SGA分娩的风险增加显著相关.
- 童年逆境可以为长期和代际健康问题建立轨迹.
- 需要进一步的研究来阐明将CM与不良出生结果联系在一起的机制.
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