生物信息学分析并揭示了动脉样硬化和牙周炎之间的潜在交叉基因和免疫关系
Wenyuan Dong1, Yuxin Gong1, Bin Yang1
1Second hospital of Shanxi medical university, Taiyuan, 030000, China.
Scientific reports
|June 27, 2023
概括
牙周炎和动脉样硬化共享免疫路径. 研究人员确定BTK和ITGAL是关键的交叉通话基因,突出了这些炎症性疾病中的巨细胞和T细胞.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 心血管疾病 心血管疾病
背景情况:
- 牙周炎 (PD) 和动脉样硬化 (AS) 是具有免疫系统参与的炎症性疾病.
- 这两种情况都与系统性健康问题有关,这表明共享的潜在机制.
- 了解PD和AS之间的免疫交叉是开发有效治疗方法的关键.
研究的目的:
- 确定常见的免疫细胞和牙周炎和动脉样硬化之间的潜在交叉基因.
- 评估已识别的交叉通话基因的诊断和预测价值.
- 探索免疫反应在两种疾病的发病过程中的作用.
主要方法:
- 在PD和AS中免疫细胞的权重基因共同表达网络分析 (WGCNA).
- 鉴定差异表达基因 (DEG) 和免疫相关基因 (IRG).
- 使用机器学习模型和诊断名录来评估基因预测价值.
主要成果:
- 确定了14个共同表达的免疫相关基因,BTK和ITGAL被选为关键交叉基因.
- 基于BTK和ITGAL的诊断名录显示出强大的疾病诊断预测能力.
- 基因组丰富分析 (GSEA) 揭示了在抗原呈现和免疫调节中的共同作用.
结论:
- BTK和ITGAL是牙周炎和动脉样硬化之间的重要交叉基因,可能有助于诊断和治疗.
- 巨细胞和T细胞在两种疾病的炎症过程中都是关键的免疫参与者.
- 生物信息学分析提供了有关PD和AS的遗传相关性和免疫机制的见解.
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