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在Nellore牛群中确定候选致命单元型和基因组关联与产后死亡率和生殖特征

Patrícia Iana Schmidt¹, Lucio Flavio Macedo Mota², Larissa Fernanda Simielli Fonseca²

¹Animal Science Department, School of Agricultural and Veterinary Sciences, São Paulo State University (Unesp), Via de Acesso Paulo Donato Castellane S/N, Departamento de Zootecnia, Jaboticabal, SP, 14884-900, Brazil. pati.iana@hotmail.com.

Scientific reports

|June 27, 2023

概括

基因组查在内罗尔牛群中发现了30种致命的衰退类型,对生殖和生存产生了负面影响. 识别载体可以改善群体管理,减少遗传缺陷.

科学领域:

动物遗传学动物遗传学
基因组选择基因组选择
量化遗传学量化遗传学

背景情况:

衰退性致死性等位基因通过导致生育率和生存率下降,显著影响牲畜生产率.
基因组信息有助于识别影响牛群经济重要特征的遗传缺陷.

研究的目的:

为了选Nellore牛基因组以寻找致命的递归单元类型,使用同胞性偏差.
将SNP标记物与致命单元型附近的SNP标记物与母牛重生 (HR),产后死亡率 (PNM) 和稳定性 (STAY) 相关联.

主要方法:

将62,022头Nellore牛的基因型定型并归因于一个高密度面板 (777,962个SNP标记).
计算了预期的同位素和观察零同位素的概率,以检测致命的单质类型.
在全基因组关联研究 (GWAS) 中利用退行基因组繁殖值 (G) EBV,并对候选基因进行功能分析.

主要成果:

确定了30种具有高预期频率的哈普洛类型,但没有观察到同位素,这表明致命性.
这些单元类型中的等位基因对PNM,HR和STAY产生了负面影响.
GWAS确定了与研究特征的性能下降相关的显著SNP标记物,涉及组织发育和免疫系统途径.

结论:

致命的衰退性单元型在内罗尔牛中构成了重大遗传挑战,影响了关键的生产特征.
识别这些单元型的载体对于有效的育种计划至关重要,以尽量减少遗传损失.
功能分析强调了组织发育和免疫系统基因在这些有害影响中的作用.

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