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Updated: Jul 25, 2025

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Immunostaining to Visualize Murine Enteric Nervous System Development
Published on: April 29, 2015
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在中枢神经系统和肠道神经系统中发送的同类2 (DISP2) 的定位模式
Marvin Heimke1, Florian Richter2, Tillmann Heinze1
1Institute of Anatomy, Kiel University, Olshausenstrasse 40, 24098, Kiel, Germany.
Journal of molecular neuroscience : MN
|June 27, 2023
概括
发送同源2 (DISP2) 主要存在于中央神经系统和肠道神经系统的神经元中. 这种神经元局部化表明DISP2在神经系统的发育和功能中起作用.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 发送的同类蛋白 (DISP) 调节对胚胎发育至关重要的刺信号.
- DISP2与神经元发育和认知功能有关,但其神经系统局部不明.
研究的目的:
- 研究DISP2在哺乳动物中枢神经系统 (CNS) 和外周神经系统中的表达特征和局部化.
- 描述DISP2在不同物种的神经元和质细胞内的细胞分布.
主要方法:
- 对人类组织中DISP2表达的转录组数据集的分析.
- 人类和老鼠中枢神经系统和肠道神经系统 (ENS) 的双标签免疫组织化学.
- 在小鼠初级ENS培养物中使用神经元和质标记物的局部化研究.
主要成果:
- 转录组数据显示,DISP2在中枢神经系统和内枢神经系统的神经细胞类型中的表达占主导地位.
- 免疫组织化学检测显示DISP2局限于PGP9.5阳性神经元,而不是S100阳性质细胞.
- 在人类和老鼠的中枢神经系统和内脏神经系统中,在神经元体和过程中发现了DISP2.
结论:
- DISP2主要定位在中枢神经系统和内枢神经系统的神经元细胞内.
- 这些发现支持DISP2在神经元功能和神经元系统内的发育中的潜在作用.
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