在患有饮食障碍的妇女中,童年虐待和皮质折叠之间的关联
Giammarco Cascino1, Antonietta Canna2, Andrea Gerardo Russo3
1Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Salerno, Italy.
The European journal of neuroscience
|June 27, 2023
概括
儿童虐待 (CM) 与饮食障碍 (ED) 的妇女左侧中圈皮质折叠减少有关. 这一发现证实了这一发现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 众所周知,童年虐待 (CM) 影响了饮食障碍 (ED) 患者的临床和生物特征.
- 局部化指数 (LGI) 是一种神经成像指标,可以量化皮质折叠,可能反映出与CM相关的结构性大脑变化.
研究的目的:
- 研究儿童虐待与被诊断患有饮食障碍的妇女的局部化指数 (LGI) 之间的关联.
- 探索CM是否会影响神经性厌食症 (AN) 和神经性嗜食症 (BN) 患者在特定大脑区域的皮质结构.
主要方法:
- 磁共振成像 (MRI) 扫描对26名AN妇女和24名BN妇女进行了扫描.
- 参与者填写了童年创伤问卷,以评估虐待历史.
- 使用FreeSurfer处理神经成像数据,并使用一般线性模型分析LGI地图,以比较受虐待和未受虐待的群体.
主要成果:
- 与未遭受虐待的个人相比,有童年虐待史的个人在左侧中椎中表现出明显较低的LGI.
- 在受虐待和未受虐待组之间的右半球LGI没有发现显著差异.
结论:
- 在患有饮食障碍的妇女中,童年虐待与左侧中圈皮质折叠的减少有关.
- 这些发现表明,CM可能有助于ED患者的独特生物特征,支持"虐待生态表型"假设.
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