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纤维素降解产物和慢性阻塞性肺病患者的生存率:一个协议化的前性观察性研究
Peter Kamstrup1, Pradeesh Sivapalan1, Christian Rønn1
1Section of Respiratory Medicine, Copenhagen University Hospital Herlev and Gentofte, Hellerup, 2900, Denmark.
Respiratory research
|June 27, 2023
概括
慢性阻塞性肺病 (COPD) 患者的高D-二聚物水平与死亡风险增加相关. 然而,由于调整信号较弱,不建议在COPD门诊患者中进行非选择性风险分层.
科学领域:
- 肺部医学 肺部医学
- 心血管医学 心血管医学
- 生物标志物 生物标志物
背景情况:
- 慢性阻塞性肺病 (COPD) 患者表现出心血管疾病的高患病率,包括血栓塞栓症.
- 提升的D-二聚合物水平,纤维素降解的标志物,与一般和COPD人群的全因死亡率有关.
- 了解D-dimer在COPD中的作用对于风险评估和管理至关重要.
研究的目的:
- 为了研究D-二次体水平与COPD患者全因死亡率之间的关联.
- 评估抗凝血剂和抗血小板治疗对这种协会的影响.
- 为了确定中度至重度COPD门诊患者的D-二次体水平的分布.
主要方法:
- 从哥本哈根大学医院的COPD门诊病人的稳定D-二次体水平的回顾性分析.
- 利用丹麦登记册将D-二次体测量与死亡率数据联系起来.
- 采用Cox比例危险回归和多重线性回归来分析结果.
主要成果:
- 在高D-二次体和全因死亡率 (HR:2.3) 之间发现了一个未经调整的关联.
- 在完全调整的分析中,这种关联被减弱了 (HR: 1.8).
- 高D-二次数与活着和出院日数 (pDAOH) 的比例降低有关,调整模型中的结果减弱.
结论:
- 中度至重度COPD患者的D-二聚合物水平升高表明死亡的可能性更高.
- 观察到的关联在调整后的分析中并不强大.
- 目前的研究结果不支持在COPD门诊患者中对D-二次体进行非选择性风险分层的常规使用.
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