对抗Qinlian Decoction通过准昼夜免疫功能来治疗无症状高尿血症
Xiaojun Wang1,2, Xuanqi Liu3, Qiushuang Gao4
1Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, No 221West Yan-An Road, Shanghai, 200040, China.
Chinese medicine
|June 27, 2023
概括
基因精 (GGQLD) 通过调节免疫细胞和生理时钟基因来帮助无症状的高尿血症. 这种传统中医药减少了特定的免疫细胞比例和关键的炎症因素,提供了一种新的治疗方法.
科学领域:
- 传统中国医药 传统中国医药
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
背景情况:
- 无症状高尿路血症 (HUA) 是一个临床挑战.
- Gegen Qinlian Decoction (GGQLD) 是一种传统的中医药,有着治疗HUA的历史.
- 在HUA中GGQLD的有效性背后的精确机制仍未完全阐明.
研究的目的:
- 研究GGQLD在治疗无症状HUA中的分子机制.
- 识别受GGQLD影响的关键途径和细胞点.
- 探索免疫细胞和昼夜节律在GGQLD治疗作用中的作用.
主要方法:
- 网络药理学确定了潜在的治疗途径.
- 大量RNA测序分析了近接管上皮细胞 (PTEC) 中的转录组变化.
- 流细胞计,ELISA,分子对接和分子动力学模拟评估了细胞和分子相互作用.
主要成果:
- GGQLD治疗调节了与免疫相关的途径,特别影响了先天性淋巴细胞 (ILC) 的发育.
- 在HUA患者中,GGQLD降低了ILC3s的比例和IL-18和IL-1β水平.
- 周围血液单核细胞 (PBMC) 中的日间钟基因表达受GGQLD的调节,确定了特定的化合物相互作用.
结论:
- 通过调节ILC细胞群,GGQLD对无症状HUA产生治疗作用.
- 生物钟基因表达的调节是GGQLD在HUA治疗中的关键机制.
- GGQLD的作用涉及与免疫和时钟相关途径的复杂相互作用.
相关概念视频
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
93
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
93
Methods of reducing fever
706
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
706


