高风险怀孕中阻塞性睡眠呼吸暂停的治疗:一个多中心随机对照试验
Visasiri Tantrakul1,2,3,4, Atiporn Ingsathit5, Somprasong Liamsombut3,4
1Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Respiratory research
|June 27, 2023
概括
持续正气道压力 (CPAP) 显著降低了阻塞性睡眠呼吸暂停 (OSA) 的高风险孕妇的透气压和子宫前发病率. 这种治疗可以在整个怀孕期间持续控制血压.
科学领域:
- 产科和妇科 产科和妇科
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
背景情况:
- 妊娠期间阻塞性睡眠呼吸暂停 (OSA) 与胎盘问题和子宫前有关.
- 持续正气道压力 (CPAP) 可以通过改善血压和减少子宫前发病率来减轻这些风险.
研究的目的:
- 评估CPAP在控制血压和预防患有OSA的高风险孕妇产前的疗效.
- 评估CPAP对血压调节和孕前率的影响.
主要方法:
- 一个多中心的,开放的,随机对照试验比较了CPAP治疗与通常的产前护理.
- 参与者是孕妇 (≥18岁) 患有高风险疾病和OSA,在第一或第二个三个月内招募.
- 主要终点:血压;次要终点:孕前的发生率. 进行了治疗意向分析.
主要成果:
- CPAP治疗显著降低了腹压血压 (DBP) -2.2 mmHg (p=0.014) 并显示在整个怀孕期间持续下降.
- 在CPAP组中,孕前的发生率为13.1%,而在常规护理组中为22.3% (p=0.032).
- 预防产前需要治疗的数量为11.
结论:
- CPAP治疗有效地减少了高风险的孕妇中轻度至中度OSA的DBP和孕前的发生率.
- 在CPAP治疗期间,在整个妊娠期间观察到持续的DBP降低.
- CPAP是高风险怀孕中OSA的可行的治疗选择,以改善母亲和胎儿的结果.
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