尿病原体的抗生素耐药性在女性群体中的演变:一个连续的多年比较分析
Cristian Mareș1,2, Răzvan-Cosmin Petca1,3, Răzvan-Ionuț Popescu1,3
1Department of Urology, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania.
Antibiotics (Basel, Switzerland)
|June 28, 2023
概括
这项研究追踪了2018-2022年尿路感染 (UTI) 中的抗生素耐药性. 结果显示,抗药性增加,特别是对levofloxacin的抗药性增加,强调需要持续监测和更新治疗指南.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 尿路感染 (UTI) 在女性中很常见,并且经常用抗生素治疗.
- 抗生素耐药性增加需要监测泌尿病原体发生率和耐药性模式.
- 了解局部耐药性趋势对于有效的尿路感染管理至关重要.
研究的目的:
- 以回顾分析尿病原体的发病率及其不断变化的耐药率.
- 评估尿路感染抗菌素耐药性的短期和中期趋势.
- 根据地方区域的耐药性数据,为当前的治疗建议提供信息.
主要方法:
- 追溯分析了1124个来自"Prof. Dr. Th. "的阳性尿液培养物. 布尔吉尔的临床医院.
- 数据是在2018年至2022年期间的三个四个月期间收集的.
- 识别常见的泌尿病原体,并评估它们对关键抗生素的耐药性.
主要成果:
- *大肠杆菌是最常见的尿路病原体 (54.53%),其次是 *克莱布西埃拉* spp. (16.54%) 和 *Enterococcus* spp. 的使用. (14.59%).这是一个很大的问题.
- 在格拉姆阴性泌尿病原体中,最高的耐药性观察到的是勒沃克萨辛 (30.69%),塞夫塔齐迪姆 (13.77%) 和阿米卡辛 (9.86%).
- 在格拉姆阳性尿病原体中发现了对勒沃素和青素的显著耐药性,在格拉姆阴性尿病原体中观察到塞夫塔齐迪姆和勒沃素的日益增加的趋势.
结论:
- 对抗生素耐药性模式的持续评估对于指导尿路感染治疗至关重要.
- 该研究强调了与地方区域背景相关的抗生素耐药性的具体趋势.
- 数据支持对尿路感染进行更新的实证抗生素治疗策略的需要.
相关概念视频
01:30Development of Antibiotic Resistance
46
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
46
00:57Antibiotic Selection
54.8K
Overview
54.8K
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
16
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
16
01:26Urine Studies II: Urine Culture and Sensitivity Test
58
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
58
01:25Urinary Tract Infection II: Pathophysiology
20
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
20