在Hidradenitis Suppurativa中进行全身抗生素治疗:对治疗景观和当前问题的审查
Elisa Molinelli1, Edoardo De Simoni1, Matteo Candelora1
1Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60126 Ancona, Italy.
Antibiotics (Basel, Switzerland)
|June 28, 2023
概括
系统性抗生素是治疗慢性炎症性皮肤疾病 - - 补性腺炎 (HS) 的首要治疗方法. 本综述探讨了抗生素的使用,耐药性和毒性等局限性,以及将抗生素与生物药物结合的未来策略.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 补腺炎 (HS) 是一种慢性,炎症性皮肤疾病,导致疼痛的结节和鼻道.
- 系统性抗生素是HS的初始药理治疗方法,因为它们具有抗炎和抗菌作用.
研究的目的:
- 审查有关HS管理中全身抗生素使用的当前问题.
- 批判性地分析抗生素治疗的局限性,包括耐药性和毒性.
- 讨论抗生素与新兴生物药物的持续作用.
主要方法:
- 叙述对当前关于性炎和抗生素治疗的文献的综述.
- 在HS治疗中对抗生素耐药性和毒性的批判性分析.
- 评估抗生素与生物药物和外科手术联合作用.
主要成果:
- 尽管存在担忧,但抗生素仍然是hidradenitis suppurativa的有效治疗选择.
- 抗生素耐药性和毒性是它们使用的重大限制.
- 对HS的生物药物的研究正在推进,但抗生素仍然占据着他们的位置.
结论:
- 系统性抗生素是HS管理的基石,但必须解决它们的局限性.
- 未来的HS治疗可能涉及组合疗法,包括抗生素与生物药物或作为手术前管理.
- 需要继续进行研究,以优化抗生素策略,并减轻HS患者的不良影响.
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