抗生素敏感性模式和病毒性相关因子,来自三级保健医院的抗万科胺素耐药肠球菌分离物
Arockia Doss Susai Backiam1, Senbagam Duraisamy2, Palaniyandi Karuppaiya2
1Department of Microbiology, Vivekanandha College of Arts and Science for Women (Autonomous), Tiruchengode 637303, India.
Antibiotics (Basel, Switzerland)
|June 28, 2023
概括
多种耐药性肠球菌,特别是抗万科米菌株,在临床环境中很普遍. 这些耐药细菌具有显著的毒性因子,有助于持续感染,并突出了针对性干预的必要性.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 肠球菌是重要的医院病原体.
- 增加抗微生物药物耐药性,特别是抗万科米耐药性,是全球健康问题.
- 病毒性因素有助于肠球菌的致病性和感染持久性.
研究的目的:
- 调查从临床标本中分离的肠球菌中多药耐药性 (MDR) 和毒性因子的流行情况.
- 鉴定菌素耐药性肠球菌 (VRE) 及其相关遗传决定因素的特征.
- 了解病毒性因子在VRE感染中的作用.
主要方法:
- 从1575个临床标本中分离和识别肠球菌.
- 使用磁盘扩散方法进行抗生素敏感性测试.
- 对毒性因子 (凝酶,蛋白酶,血清素,生物膜) 和耐药基因 (vanA,vanB) 的表型和基因型分析.
主要成果:
- 百分之四十五的Enterococcus faecalis和百分之二十九的Enterococcus faecium是最常见的物种.
- 观察到对烯 (70%) 和万科米辛 (43%) 的高水平耐药性.
- 11%的分离物是MDR,大多数VRE都含有vanA基因.
- 毒性因子 (凝酶,蛋白酶,血清素,生物膜) 的患病率很高,特别是在VRE.
- gelE是最常见的毒性基因,其次是 esp,asa,ace 和 cylA.
结论:
- 抗万科胺素的Enterococcus faecalis和Enterococcus faecium是临床环境中的重大威胁.
- 在VRE中存在多个毒性因子,这有助于它们的致病性.
- 了解这些因素对于制定有效的策略来对抗持续性肠球菌感染至关重要.
相关概念视频
Development of Antibiotic Resistance
46
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
46
Antibiotic Selection
54.8K
Overview
54.8K
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K


