在COVID-19患者中的抗菌管理:那些播种的人即使在艰难时期也会收获
Marcella Sibani1, Lorenzo Maria Canziani2, Chiara Tonolli3
1Infectious Diseases Department, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.
Antibiotics (Basel, Switzerland)
|June 28, 2023
概括
随着COVID-19的流行,抗微生物药物管理 (AS) 受到干扰. 在大流行期间实施校准的AS活动显著减少了抗生素消耗,防止了不适当的治疗.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 医院管理局 医院管理局
背景情况:
- 由于COVID-19大流行,需要将抗微生物管理 (AS) 的资源转向管理COVID-19患者.
- 医院AS计划需要适应,以保持在公共卫生危机期间的有效性.
研究的目的:
- 评估COVID-19对抗微生物管理 (AS) 活动的影响.
- 评估大流行期间COVID-19患者抗生素消费的变化.
- 确定重新实施的AS活动在控制抗生素使用方面的有效性.
主要方法:
- 采用了受控的前后研究设计,将三次COVID-19浪潮的抗生素消费量与12个月的流行前基线进行比较.
- 抗生素使用数据从三级医院的四个单位收集,包括在第二波期间加强AS活动的干预单位.
- 消费总体分析并按照世卫组织AWaRe分类进行分层,使用每1000个患者日 (PD) 的定义剂量 (DDD) 和治疗日 (DOT).
主要成果:
- 在第一波疫情期间,多个单位的抗生素消费量 (DOT/1000 PD) 显著超过了2019年的水平.
- 在重新引入AS活动后,与大流行前时期相比,干预单位的抗生素消耗显著下降.
- 抗生素管理干预措施导致整体抗生素使用减少,并积极影响"观察"抗生素和piperacillin-tazobactam的使用.
结论:
- 校准的抗微生物管理 (AS) 活动对于防止在流行病期间不适当使用抗生素至关重要.
- 在公共卫生紧急情况下投资AS计划对于优化抗生素治疗至关重要.
- 该研究表明,在应对新型传染病爆发时,调整AS计划的可行性和积极影响.
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