糖尿病足部感染的系统性抗菌疗法:系统性审查的概述
Angela Wright1,2, Stephen Wood1, Janath De Silva3
1Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
Antibiotics (Basel, Switzerland)
|June 28, 2023
概括
对糖尿病足感染 (DFI) 的最佳抗微生物选择仍然不确定. 这次审查发现,很少有证据表明,一种全身性抗菌药物治疗方案在DFI治疗疗效或安全方面优越.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 糖尿病足部感染 (DFI) 是糖尿病的一个重要并发症,导致相当大的发病率.
- 关于最有效和最安全的全身抗菌药物治疗DFI的临床不确定性仍然存在.
研究的目的:
- 批判性地评估最近对治疗糖尿病脚部感染的全身抗微生物药物的疗效和安全性的系统性审查.
- 综合现有证据,为DFI管理提供临床决策信息.
主要方法:
- 在Medline,Embase,CENTRAL和CINAHL数据库以及PROSPERO注册表中进行了全面的搜索,以查找2015年1月至2023年1月期间发表的系统审查.
- 包括专注于DFI系统性抗菌剂的系统性审查,评估临床感染解决和并发症. 质量评估使用了AMSTAR-2工具.
主要成果:
- 分析中包括了六项系统性审查,包括29项单个研究.
- 在24种不同的抗微生物药物治疗方案中,没有观察到临床分辨率的统计学上显著差异.
- 提格环素与埃尔塔尼姆±万科米辛相比显示非劣势,并与增加的不良事件有关.
结论:
- 目前的系统审查证据对任何单一的全身抗微生物药物治疗糖尿病脚部感染的优越性提供了最小的支持.
- 需要进一步进行高质量的研究,以确定DFI的最终最佳治疗策略.
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