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全球疫苗:候选者和剩余的挑战

Luís Fernando Parizi¹, Naftaly Wang'ombe Githaka², Carlos Logullo^3,4

¹Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.

Animals : an open access journal from MDPI

|June 28, 2023

概括

开发有效的疫苗是具有挑战性的,因为复杂的宿主相互作用和冗余的生物通路. 本综述探讨了为全球健康创造通用疫苗的进展和障碍.

科学领域:

分子生物学分子生物学
寄生虫学的寄生虫学
疫苗学疫苗学疫苗学

背景情况:

测序技术的进步为生理学提供了洞察力.
了解-宿主分子相互作用仍然不完整,阻碍了疫苗开发.
和病原体的扩散对动物和人类健康构成越来越大的风险.

研究的目的:

审查在开发通用疫苗方面的挑战和进展.
为多抗原疫苗识别有前途的抗原候选人.
讨论疫苗开发的未来研究方向.

主要方法:

关于的分子生物学和奥米克学研究的最新文献的综述.
对多抗原疫苗抗原选择的挑战进行分析.
在不同宿主物种中评估疫苗的疗效.

主要成果:

欧米克研究已经确定了潜在的疫苗免疫原体.
选择抗原是复杂的,因为分子路径冗余.
疫苗的研发落后于预期.

结论:

迫切需要针对多个物种及其病原体的疫苗.
克服抗原选择方面的挑战对于有效的疫苗至关重要.
需要进一步的研究来推进通用疫苗的开发.

关键词:

交叉保护交叉保护寄生虫寄生虫是一种寄生虫.一个小小的.控制的控制方法疫苗疫苗疫苗疫苗

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Vaccinations

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.