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生物活性玻璃及其聚合物复合物的增材制造作为骨组织工程支架:一篇评论
Lizhe He1,2, Jun Yin2, Xiang Gao3
1Center for Medical and Engineering Innovation, The First Affiliated Hospital of Ningbo University, Ningbo 315010, China.
Bioengineering (Basel, Switzerland)
|June 28, 2023
概括
增材制造 (AM) 能够创建复杂的生物活性玻璃 (BG) 和BG/聚合物支架,用于骨愈合. 这些先进的支架提供了针对患者的特定设计和受控的材料分配,以改善骨缺陷的修复.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 材料工程 材料工程 材料工程
背景情况:
- 生物活性玻璃 (BG) 和其聚合物复合物对骨缺陷愈合支架有希望.
- 制造复杂的几何形状和控制BG/聚合物支架的降解仍然是一个挑战.
- 增材制造 (AM) 为创建复杂的BG和BG/聚合物结构提供了一个解决方案.
研究的目的:
- 审查BG和BG/聚合物复合结构支架用于骨组织工程的AM的最新进展.
- 探索各种AM技术的处理基于BG的材料的能力.
- 突出AM制造的脚手架在改善骨缺陷愈合方面的潜力.
主要方法:
- 在Scopus数据库上进行相关出版物的文献搜索.
- 基于不同无机玻璃成型剂和BG/聚合物复合材料的BG特性审查.
- 分析AM技术,包括融挤出,直接墨水写作,粉末床融合和光聚合.
主要成果:
- 通过AM,可以制造具有明确形状和复杂多孔结构的BG和BG/聚合物支架.
- 各种AM技术与加工BG和BG/聚合物材料兼容.
- 机械制造允许针对患者的特定设计和按需的生物材料在支架上的空间分布.
结论:
- 在AM制造的BG和BG/聚合物复合体支架对于骨缺陷愈合有价值.
- 能够创建针对患者的特定设计和控制材料分布的能力可以提高治疗效率.
- 未来的骨缺陷愈合可以使用这些先进的支架更安全,更高效.
相关概念视频
01:55Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:18The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...