自动levothyroxine剂量算法用于患有哈希莫托甲状腺炎的患者
Ravi Sharma1, Verena Theiler-Schwetz2, Christian Trummer2
1Institute of Automation and Control, Graz University of Technology, 8010 Graz, Austria.
Bioengineering (Basel, Switzerland)
|June 28, 2023
概括
这项研究开发了一种数字算法,用于为哈希莫托氏甲状腺炎患者自动给定levothyroxine剂量. 基于模型的控制器有效调节甲状腺激素水平,旨在实现甲状腺平衡状态.
科学领域:
- 内分泌学 在内分泌学.
- 控制系统工程 控制系统工程
- 计算生物学 计算生物学
背景情况:
- 甲状腺功能低下症,通常是由 Hashimoto 的甲状腺炎引起的,需要甲状腺激素替代疗法.
- 目前的莱沃甲状腺素剂量需要频繁的患者访问,并且由于个体间的变化,缺乏标准化的指导.
- 达到最佳的甲状腺激素水平 (euthyroid状态) 对于患者的福祉至关重要.
研究的目的:
- 设计一个强大的,基于模型的数字算法,用于在哈西莫托氏甲状腺炎患者中自动给定levothyroxine剂量.
- 以数学模型来模拟甲状腺功能的动态行为,以精确调节激素.
- 通过自动化剂量调整,减少频繁临床检查的需要.
主要方法:
- 甲状腺激素动态的数学建模.
- 应用自动控制理论用于算法设计.
- 使用Thyrosim平台进行数值模拟,以评估算法的性能.
主要成果:
- 成功设计了一种基于模型的强大levothyroxine剂量算法.
- 模拟显示,甲状腺激素度的有效调节,使甲状腺激素水平达到平衡状态.
- 该算法在患者参数的模拟变化中显示出可靠的性能.
结论:
- 开发的数学模型作为未来自动莱沃西剂量系统的基础.
- 拟议的强大的反循环代表了计算机辅助甲状腺剂量的重大进步.
- 这种方法为个性化和自动化的甲状腺功能低下症管理提供了一个有希望的方向.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K
01:16Insulin: Dosing Regimen and Adverse Effects
214
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
214
01:01Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
4.2K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.2K
01:18Functions of Thyroid Hormones
2.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.9K
01:11Renal Failure: Dose Adjustments
127
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
127