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在肺移植中使用介质干细胞疗法

Antti I Nykänen^1,2,3, Mingyao Liu^1,2, Shaf Keshavjee^1,2

¹Latner Thoracic Surgery Research Laboratories, Toronto General Research Hospital Institute, University Health Network, Toronto, ON M5G 1L7, Canada.

Bioengineering (Basel, Switzerland)

|June 28, 2023

概括

介酶体 stromal 细胞 (MSC) 在保护捐赠者的肺部免受损伤和肺部移植后的排斥方面表现有前途. 研究探索MSCs用于预防和治疗慢性肺异位移植功能障碍 (CLAD).

科学领域:

免疫学和再生医学
移植科学移植科学

背景情况:

肺移植是末期肺病的关键治疗方法.
挑战包括缺血-再输液损伤,移植功能障碍和慢性肺异位移植功能障碍 (CLAD).

研究的目的:

在实验性肺移植中审查介质细胞 (MSCs) 的使用.
评估MSC在预防和治疗缺血-再输液损伤,非免疫反应和CLAD方面的潜力.
通过ex vivo肺 perfusion (EVLP) 和基因工程来探索MSC输送.

主要方法:

关于MSCs在供体肺部保护中的实验研究的综述.
对MSC用于CLAD预防/治疗的实验和临床研究的分析.
讨论EVLP作为MSC交付的平台.

主要成果:

MSCs表现出抗炎和保护膜效应.
实验数据表明,MSCs可以减轻肺损伤和非免疫反应.
目前正在调查MSCs在管理CLAD方面的潜力.

结论:

MSCs为改善肺移植结果提供了一个有希望的治疗途径.
EVLP为MSC管理提供了一个有效的平台.
基因工程可能会提高MSC的治疗疗效.

关键词:

细胞治疗疗法细胞治疗疗法活体肺外 perfusion 透肺外 perfusion 活体肺外 perfusion 透基因治疗的基因疗法肺部移植肺部移植介质细胞干细胞介质细胞干细胞

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