系统性免疫抑制是口腔癌的危险因素吗? 一个系统的审查和元分析
Romeo Patini1, Massimo Cordaro1, Denise Marchesini1
1Department of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario "A. Gemelli"-IRCCS Rome, 00135 Rome, Italy.
免疫抑制会增加口腔癌的风险. 定期查对于免疫抑制个体至关重要,以早期检测癌前病变并预防口腔癌的发展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 免疫抑制和全身癌症之间的联系已经确立.
- 在免疫抑制群体中,口腔癌的风险不太清楚.
- 免疫抑制显著影响免疫监测,可能影响口腔癌的发展.
研究的目的:
- 系统地审查和评估免疫抑制与口腔癌发病率之间的关联.
- 量化免疫抑制患者口腔癌风险的增加.
- 在脆弱人群中为口腔癌查提供临床实践的信息.
主要方法:
- 对 MEDLINE,Scopus 和 Web of Science 数据库的系统文献审查,截至 2023 年 4 月.
- 由两位作者进行独立的重复审查,评估偏见风险和证据质量 (纽卡斯尔-太华尺度,GRADE).
- 从2843个已识别的文章中包含44项研究,用于定性和定量分析.
主要成果:
- 免疫抑制被证实是患口腔癌的危险因素.
- 定量分析表明风险增加范围为0.2%至1% (95%CI:0.2%至1.4%).
- 包括的研究通常表现出高到中等的方法质量.
结论:
- 免疫抑制患者在统计学上面临明显增加患口腔癌的风险.
- 持续和准确的随访对于早期检测这种群体中具有恶性潜在的口腔病变至关重要.
- 积极的监测策略对于拦截免疫抑制个体的口腔癌进展至关重要.
更多相关视频
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
相关概念视频
Tumor Immunotherapy
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Psychoneuroimmunology: Diabetes and Cancer
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
