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萨尔茨堡皮层表面计算器 (SAPESUCA):第一个基于网络的应用程序,用于对皮层表面积的量化

Tarkan Jäger¹, Philipp Schredl¹, Daniel Neureiter²

¹Department of Surgery, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

|June 28, 2023

概括

一个新的工具SAPESUCA标准化了腹膜表面积 (PSA) 测量,用于接受细胞减小手术和高温腹膜内化疗 (HIPEC) 的结直肠癌患者. 这使得基于手术后剩余的PSA精确的化疗剂量.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
医疗信息学医疗信息学

背景情况:

结肠直肠癌中的腹转移显著恶化了预后.
细胞还原性手术 (CRS) 与高热性腹腔内化疗 (HIPEC) 结合,提供了有前途的结果,但缺乏标准化.
精确量化腹表面积 (PSA) 对于治疗规划和实施至关重要.

研究的目的:

引入第一个标准化工具,萨尔茨堡PEritoneal表面计算器 (SAPESUCA),用于CRS和HIPEC程序中的PSA量化.
为了能够根据切除和剩余的PSA精确调整化疗剂量.
在一组结直肠癌患者中验证SAPESUCA工具.

主要方法:

萨佩苏卡是使用R-Shiny框架开发的.
该算法整合了患者的身体表面积和腹腔癌指数 (PCI) 数据.
对23名结肠癌患者进行了验证,这些患者接受了27种基于氧沙的HIPEC治疗.

主要成果:

在CRS之前,SAPESUCA的PSA平均值为18,613厘米,在CRS之后为13,681厘米.
腹膜切除术的程度与PCI得分和术后发病率有显著的相关性.
模拟的氧沙剂量在CRS之前和之后显示出显著的差异 (558 mg/m2与409 mg/m2).

结论:

SAPESUCA是第一个免费的,基于网络的应用程序,用于CRS后的标准化PSA测定.
该工具可方便准确调整化学疗法剂量,以适应剩余的PSA.
标准化PSA测量对于优化HIPEC治疗在腹癌的疗效至关重要.

关键词:

R闪亮的应用程序细胞减小手术细胞减小手术超热内皮层内化学疗法超热内皮层内化学疗法内药物剂量内药物剂量腹癌指数腹癌指数腹膜转移的发生.腹膜表面积的周周表面积.腹膜表面的恶性瘤基于Web的应用程序.

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