相关实验视频

Updated: Jul 25, 2025

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells

Published on: May 12, 2023

肺癌中新兴的新药:双特异和ADC是新的范式吗?

Amanda Reyes¹, Rebecca Pharaon¹, Atish Mohanty¹

¹Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 910102, USA.

|June 28, 2023

概括

新型肺癌治疗方法,如双特异性抗体和抗体-药物合物,显示出克服非小细胞肺癌 (NSCLC) 治疗耐药性的前景. 这些创新疗法针对多种基质或直接向瘤细胞提供化疗.

科学领域:

在瘤学瘤学.
癌症治疗方法癌症治疗方法

背景情况:

肺癌是癌症死亡的主要原因之一.
非小细胞肺癌 (NSCLC) 占肺癌病例的85%.
对NSCLC的不断发展的治疗方法包括免疫疗法和向疗法.

研究的目的:

研究非小细胞肺癌 (NSCLC) 的新疗法策略.
评估双特异性抗体和抗体-药物合物在克服治疗耐药性的潜力.

主要方法:

对双特异性抗体的审查和初步评估.
对抗体与药物合物的审查和初步评估.

主要成果:

双特异性抗体提供多基质向能力.
抗体-药物联体使得有针对性的化疗可以提供.
这两种方法在临床前评估中都显示出潜力.

结论:

双特异性抗体和抗体-药物结合体代表了NSCLC治疗中的有希望的创新.
这些新的方法可能有助于克服对当前疗法的耐药性.

关键词:

轴轴信号传输系统轴轴信号传输系统突变的EGFR发生了突变.由于EGFR的耐药性,所以我们可以使用它.在HER2中,HER2是HER2.在HER3中,HER3是HER3.在MET中放大放大功率.抗体 - 药物联合体两种特异性的抗体.cMet的信号传输方式免疫疗法免疫疗法非小细胞肺癌的肺癌.有针对性的治疗.

更多相关视频

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

Published on: July 12, 2018

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...