免疫检查点抑制剂在细胞癌中的挑战:当前证据和未来方向
Enrico Sammarco1, Fiorella Manfredi1, Amedeo Nuzzo1
1Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Santa Chiara Hospital, 56126 Pisa, Italy.
Cancers
|June 28, 2023
概括
免疫检查点抑制剂是晚期细胞癌的标准,但有些患者进展. 本综述检查免疫疗法再挑战作为潜在的二线治疗,探索其疗效和未来的作用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞癌是细胞癌.
背景情况:
- 免疫检查点抑制剂 (ICI) 是高级细胞癌 (RCC) 的第一线标准.
- 显著的患者群体经历了疾病进展,尽管ICI治疗.
- 在先进的RCC中,在一线ICI之后的二线治疗数据有限.
研究的目的:
- 审查目前关于免疫疗法在晚期细胞癌中重新挑战的证据.
- 探索对ICI耐药性的生物学理由.
- 总结临床疗效数据和免疫治疗的未来前景,在RCC中重新提出挑战.
主要方法:
- 对免疫疗法在细胞癌中重新挑战研究的文献综述.
- 对免疫检查点抑制剂耐药性的基础生物机制的分析.
- 从II期研究和正在进行的试验中综合发表的临床疗效数据.
主要成果:
- 初步数据表明,在一些晚期RCC患者中,免疫疗法再试剂的潜在疗效.
- 了解阻力机制对于优化重新挑战策略至关重要.
- 随机试验正在进行中,以澄清再挑战在转移性RCC中的作用.
结论:
- 免疫疗法再挑战是初始ICI失败后高级RCC的新兴策略.
- 它作为护理标准的作用尚未确立,需要进一步调查.
- 目前正在进行的研究旨在确定在耐火RCC中重新挑战的最佳使用方法.
更多相关视频
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
13.6K
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.9K
相关概念视频
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K