在空间和时间中绘制非编码RNA:在癌症进展中剖析瘤内部异质性的另一种武器
Mario Cioce1,2, Andrea Marra1,2, Daniela Rutigliano1
1Laboratory of Molecular Medicine and Biotechnology, Department of Medicine, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Cancers
|June 28, 2023
概括
瘤内异质性 (ITH) 驱动癌症进化,使多样化的细胞亚群能够动态地适应和利用资源. 了解这个复杂的生态系统是开发有效的癌症治疗的关键.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 进化生物学 进化生物学
背景情况:
- 瘤内异质性 (ITH) 越来越被认为是瘤进化的关键驱动因素.
- 癌症被概念化为一个复杂的生态系统,包括多样化的细胞亚群.
- 这些子群体表现出空间和时间的调节,采用了生存和繁殖的动态策略.
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