基于扩散权重成像的未增强的乳腺MRI协议:对乳腺癌高风险人群的回顾性单中心研究
Anna Rotili1, Filippo Pesapane1, Giulia Signorelli1
1Breast Imaging Division, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.
Diagnostics (Basel, Switzerland)
|June 28, 2023
概括
使用扩散权重成像 (DWI) 的无对比性乳房MRI显示为查高风险BRCA1/2突变载体具有前途. 这种创新方法为无症状妇女的乳腺癌检测提供了高灵敏度和特异性.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 高风险女性,如BRCA1/2突变携带者,需要有效的乳腺癌查.
- 传统的查方法可能有局限性,需要创新的方法.
研究的目的:
- 评估无对比磁共振成像 (MRI),特别是扩散权重成像 (DWI),作为乳腺癌查工具.
- 评估无症状,高风险的携带BRCA1/2突变的女性DWI的诊断性能.
主要方法:
- 来自BRCA1/2携带者的乳房MRI扫描 (DWI/ADC地图,T2-WI) 的回顾性评估 (2019年1月 - 2021年12月).
- 由两名放射科医生 (经验丰富和住院医生) 进行的独立评估,以病理诊断或长期随访为参考标准.
- 计算灵敏度,特异性,准确性和读者之间的协议 (科恩的卡帕).
主要成果:
- 分析了145名女性 (344名MRI);癌症患病率为3.2%.
- 敏感度在64-73%之间,两种阅读器的特异性为90%.
- 诊断准确率为90%,与中度的读者间一致 (κ = 0.43).
结论:
- 没有对比度的乳腺DWI,补充T2-WI,可以检测高灵敏度和特异性的BRCA1/2载体的乳腺癌.
- 这种未经增强的MRI方法显示了为特定高风险人群的独立查方法的潜力.
- 需要进一步的前性试验来证实这些发现.
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