使用通用EDOXABAN校准器确定抗Xa抑制剂血度
Annika Burger1, Jan-Dirk Studt2, Adriana Mendez3
1Department of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Diagnostics (Basel, Switzerland)
|June 28, 2023
概括
使用EDOXABAN校准器进行的通用抗Xa检测准确地测量了患者的抗凝剂水平. 这种方法支持对利瓦罗克萨班,阿皮克萨班和埃多克萨班的实验室测试,改善了临床决策.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床化学 临床化学
- 实验室医学 实验室医学
背景情况:
- 标准化直接口服抗凝剂 (DOAC) 的实验室测量对于患者安全至关重要.
- 现有的抗Xa测定可能需要针对不同抑制剂的特定校准器,使实验室工作流程复杂化.
- 一个通用校准器可以简化各种抗Xa抑制剂度的确定.
研究的目的:
- 为了评估使用edoxaban校准的通用抗Xa试验的临床性能.
- 评估该试验能够准确确定里瓦罗克萨班,阿皮克萨班和埃多克萨班的临床相关度的能力.
- 为了将检测结果与超高性能液体染色学-并联质谱法 (LC-MS/MS) 测量进行比较.
主要方法:
- 一项前性,横截面研究,涉及553名接受里瓦洛克萨班,阿皮克萨班或埃多克萨班治疗的患者.
- 使用Technochrom®抗Xa测定与Technoview®edoxaban校准器进行分析.
- 用LC-MS/MS测量药物度作为参考方法.
主要成果:
- 普遍试验和LC-MS/MS之间具有很高的整体相关性 (rs = 0.95).
- 接收器运行特征曲线 (0.960.99) 下的优秀区域用于检测治疗度.
- 对临界药物水平的高灵敏度 (92.394.8%) 和特异性 (82.294.4%).
结论:
- 全面的,以edoxaban校准的抗Xa测定表明了强大的临床性能.
- 该测定准确地预测了主要抗Xa抑制剂的临床相关度.
- 这种通用校准器方法支持对DOAC进行高效和可靠的实验室测试.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.3K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
763
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
763
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
349
The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
349
Drug Concentrations: Measurements
412
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
412
Drug Concentration Versus Time Correlation
902
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
902


