帕金森病中的冷漠:临床模式和神经生物学基础
Matthieu Béreau1,2, Vincent Van Waes2, Mathieu Servant2
1Département de Neurologie, CHU de Besançon, 25000 Besançon, France.
Cells
|June 28, 2023
概括
帕金森病 (PD) 中的冷漠在不同疾病阶段呈现不同的表现. 早期的冷漠是对多巴反应的,而晚期的冷漠与认知衰退有关,而不是.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 漠不关心,失去动力和目标导向的行为,是帕金森病 (PD) 的常见神经精神病学特征.
- 它的患病率随着PD的进展而增加,但其病理生理学和解剖学的基础仍然不清楚.
- 漠不关心涉及认知,情绪和行为组成部分,影响生活质量.
研究的目的:
- 审查帕金森病中冷漠的临床模式和治疗方法.
- 探索神经生物学基础和参与冷漠的解剖结构.
- 在PD中区分动机和认知冷漠.
主要方法:
- 本综述综合了有关帕金森病无动于衷的现有文献.
- 它检查了临床表现,神经生物学机制和解剖学途径.
- 该综述讨论了与PD不同阶段和治疗反应相关的发现.
主要成果:
- 早期PD (前期或波动性) 中的冷漠的特征是动机缺陷,与多巴胺和血清激素缺血有关,并且对多巴反应敏感.
- 在晚期PD中,冷漠表现为认知冷漠,先前的认知衰退和痴呆症,与扩散神经递质功能障碍和Lewy病理有关,并且不对多巴反应.
- 连接前额叶皮和边缘系统的解剖结构受损与冷漠有关.
结论:
- 帕金森病中的冷漠是一种复杂的综合征,根据疾病阶段有不同的亚型.
- 早期PD的动机性冷漠对多巴胺类药物有反应,而晚期PD的认知性冷漠则没有.
- 了解这些区别对于PD患者的向治疗和管理策略至关重要.
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