对肥胖和大脑的遗传洞察:结合孟德尔随机化研究和基因表达分析
Leian Chen1, Shaokun Zhao2, Yuye Wang1
1Department of Neurology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100029, China.
Brain sciences
|June 28, 2023
概括
肥胖与大脑结构的减少有关,包括皮质厚度和表面积. 这项研究表明,从肥胖到大脑异常和阿尔茨海默氏症等神经精神疾病的因果关系.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 肥胖是一个全球公共卫生问题,社会负担越来越大.
- 肥胖和大脑健康之间的关系仍然存在争议.
- 了解这种联系对于预防相关的神经疾病至关重要.
研究的目的:
- 为了研究肥胖和大脑结构变化之间的因果关系.
- 探索肥胖,大脑结构和神经精神疾病之间的潜在机制.
- 为了确定受肥胖影响的特定大脑区域.
主要方法:
- 利用孟德尔的随机化 (MR) 方法与来自GIANT,英国生物银行和ENIGMA联盟的大规模遗传和神经成像数据.
- 进行了单变量和多变量MR分析,以评估肥胖指标 (BMI,VAT,身体脂肪百分比) 和大脑结构 (皮层厚度,表面积) 之间的关联.
- 对来自艾伦人类大脑图谱 (AHBA) 的特定区域基因进行生物信息学分析,以确定潜在的生物途径.
主要成果:
- 更高的身体质量指数 (BMI) 和内脏脂肪组织 (VAT) 与减少的全球皮层厚度有因果关系.
- 肥胖度指标与较小的状状圈厚度和前形表面积有关.
- 受影响大脑区域的丰富基因参与化合物运输,神经信号传递和神经活性联体受体相互作用,显示与阿尔茨海默病和有关.
结论:
- 确定了肥胖和大脑结构异常之间的因果关系.
- 提出一种从肥胖到改变大脑结构的生物途径,可能导致神经精神疾病.
- 强调体重管理对大脑健康和神经疾病预防的重要性.
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