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植物化学物质和质瘤:通过饮食混合暴露的结果

Weichunbai Zhang¹, Ce Wang¹, Feng Chen¹

¹Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

|June 28, 2023

概括

饮食中摄入特定的植物化学物质,包括胡卜素和素,可能会降低中国成年人质瘤的风险. 这些化合物的较高消耗与这种脑癌的发生率较低有关.

科学领域:

在瘤学瘤学.
营养科学营养科学
流行病学流行病学

背景情况:

植物化学物质在预防癌症方面表现有前途,但关于质瘤的证据有限.
关于植物化学物质和质瘤的临床前数据超过了流行病学研究和剂量反应关系.
需要进一步研究饮食中的植物化学物质和人类群体中的质瘤风险.

研究的目的:

研究中国成年人中食用植物化学品摄入量与质瘤风险之间的关联.
探索特定植物化学物质和质瘤之间的剂量反应关系.
确定影响质瘤风险的关键植物化学物质.

主要方法:

一项基于医院的病例控制研究,涉及506名质瘤患者和506名对照人群.
通过使用食物频率问卷来评估饮食摄入量,以估计植物化学物质的消耗.
使用了包括WQS,BKMR和限制立方线在内的统计模型.

主要成果:

摄入较高的胡卜素,黄类,大豆异黄,素和复星与降低质瘤风险有关.
安东素和胡卜素对质瘤风险的影响更为显著.
在饮食中的植物化学物质和质瘤之间观察到非线性剂量反应关系.

结论:

增加特定植物化学物质的饮食摄入量,如胡卜素,黄酸盐,大豆异黄,酸氨酸和复星与质瘤风险降低有关.
植物化学物质在质瘤的发展和预防中发挥着潜在的重要作用.
这些发现强调了富含植物化学物质的饮食模式对大脑健康的重要性.

关键词:

贝叶斯核机器回归贝叶斯核机器回归剂量/反应关系关系质瘤质瘤是一种植物化学品植物化学品权重定量总和回归方法权重定量总和回归

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