2组先天性淋巴细胞在喘中的功能作用
Takahiro Matsuyama1, Kentaro Machida1, Keiko Mizuno1
1Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Biomolecules
|June 28, 2023
概括
第二组先天性淋巴细胞 (ILC2) 驱动喘病原体,通过独立于抗原引起呼吸道炎症. 在严重喘中增加的ILC2数量表明在疾病严重程度和潜在的类固醇耐药性方面发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 过敏和临床免疫学
背景情况:
- 喘是一种具有复杂机制的慢性呼吸道炎症疾病.
- 第二组先天性淋巴细胞 (ILC2) 是喘病原发生的关键参与者.
- ILC2s调解抗原独立的气道炎症,并可能导致类固醇耐药性.
研究的目的:
- 审查目前对ILC2s在喘中的功能作用的理解.
- 突出ILC2s在呼吸道炎症和喘中的免疫反应中的参与.
- 讨论ILC2s对喘严重程度和类固醇耐药性的潜在贡献.
主要方法:
- 本综述综合了小鼠和人类的众多研究结果.
- 对喘模型和患者的ILC2功能现有文献的分析.
- 检查ILC2s,T辅助型2 (Th2) 细胞和其他免疫细胞之间的相互作用.
主要成果:
- ILC2s通过表皮质衍生细胞因子诱导气道异性炎症.
- ILC2s与Th2细胞合作,协调2型免疫反应.
- 在喘患者中观察到较高的ILC2频率,特别是在严重的病例中.
结论:
- ILC2s是喘中呼吸道炎症的关键调解者.
- 增加的ILC2数与喘严重程度相关.
- ILC2s代表了喘管理和克服类固醇耐药性的潜在治疗标.
相关概念视频
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Lymphoid Cells and Tissues
1.3K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.3K
Asthma: Pathogenesis and Management
458
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
458
Functions of the Lymphatic and Immune System
3.8K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
3.8K
Antiasthma Drugs: Leukotriene Modifiers
371
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
371


