在患有阻塞性睡眠呼吸暂停的患者中,血清尿素II水平升高
Ante Mihovilovic1, Zoran Dogas2, Dinko Martinovic1
1Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia.
Biomolecules
|June 28, 2023
概括
在阻塞性睡眠呼吸暂停 (OSA) 患者中,血清尿素II (UII) 水平升高,与炎症和血压相关. UII可能在OSA中发挥作用.
科学领域:
- 心血管医学 心血管医学
- 睡眠医学 睡眠医学
- 内分泌学 在内分泌学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的疾病,具有显著的心血管影响.
- 尿素II (UII) 是一种强大的血管收缩剂,与各种心血管疾病有关.
- 在OSA的病理生理学中UII的作用仍在调查中.
研究的目的:
- 为了研究和比较阻塞性睡眠呼吸暂停 (OSA) 患者和健康对照者的血清尿素二 (UII) 水平.
- 探索UI水平与临床参数之间的相关性,包括呼吸暂停-呼吸暂停指数 (AHI),hs-CRP和OSA患者的血压.
主要方法:
- 一项涉及89名OSA患者和89名匹配对照者的病例控制研究.
- 病史审查,体检和多睡眠学,用于OSA诊断和严重程度评估 (AHI).
- 使用标准实验室协议测量血清尿素二 (UII) 和高灵敏性C反应蛋白 (hs-CRP) 水平.
主要成果:
- 与对照组相比,阻塞性睡眠呼吸暂停患者的血清UII水平显著更高 (3.41 ± 1.72比2.18 ± 1.36 ng/mL; p < 0.001).
- 在OSA患者中,hs-CRP水平升高 (2.87 ± 0.71 vs 1.52 ± 0.68 mg/L;p < 0.001) 和静脉压升高.
- 血清UII水平与hs-CRP (r = 0.450; p < 0.001) 和缩血压 (r = 0.317; p < 0.001) 正相关.
- 多重回归分析显示,UII水平与AHI (p = 0.013),SBP (p < 0.001) 和hs-CRP (p = 0.001) 有显著关联.
结论:
- 血清中尿素II (UII) 水平升高与阻塞性睡眠呼吸暂停 (OSA) 有关.
- 尿素II (UII) 水平与OSA患者的炎症 (hs-CRP) 和血压相关.
- 这些发现表明,尿素II (UII) 可能导致OSA复杂的病理生理学和心脏代谢并发症.
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