系统性炎症,内皮功能,以及超重/肥胖成年人牙周炎风险
Oelisoa M Andriankaja1, Cynthia M Pérez2, Ashwin Modi3
1Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA.
Biomedicines
|June 28, 2023
概括
系统性炎症标志物如ICAM-1和VCAM-1直接预测超重/肥胖成年人的牙周炎. 高hs-CRP通过ICAM-1间接影响牙周炎,突出了复杂的代谢疾病联系.
科学领域:
- 生物医学科学 生物医学科学
- 口腔健康研究研究 口腔健康研究
- 代谢性疾病研究研究
背景情况:
- 代谢疾病,全身炎症和牙周炎之间的相互作用是复杂的.
- 内皮细胞粘附分子和阿迪波内克丁作为调解者的作用尚未完全理解.
- 牙周炎是一种常见的口腔疾病,与全身健康有关.
研究的目的:
- 研究系统性炎症调解剂,内皮细胞粘附分子和与牙周炎相关的皮菌素之间的网络相互作用.
- 评估基线TNF-α,hs-CRP,ICAM-1,VCAM-1和阿迪波内克丁的血清水平是否预测牙周炎的发展.
- 评估这些生物标志物对牙周炎结果的直接和间接影响.
主要方法:
- 一项为期3年的前性研究包括597名超重/肥胖成年人 (40-65岁).
- 采用了带有负二项式回归的通用结构方程模型.
- 测量结果包括探测口袋深度 (PPD) ≥4mm的牙和探测时出血 (BOP).
主要成果:
- 基线细胞间粘附分子-1 (ICAM-1) 和血管细胞粘附分子-1 (VCAM-1) 显示对增加的PPD和BOP有显著的直接影响.
- 高灵敏度C反应蛋白 (hs-CRP) 通过ICAM-1显示对牙周炎有显著的间接影响.
- 在这个模型中,瘤亡因子-α (TNF-α) 和阿迪波内克丁没有显著的直接或间接影响.
结论:
- 血清ICAM-1和VCAM-1的升高直接导致超重/肥胖的西班牙裔成年人牙周炎的进展.
- 增加的hs-CRP通过其对ICAM-1的影响间接加剧牙周炎.
- 这些发现阐明了特定的炎症途径,将代谢健康和严重的牙疾病联系起来.
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