使用维生素D改善健康的生理基础
1Medicine, Endocrinology & Nutrition, Cardio Metabolic Institute, (Former) Rutgers University, North Brunswick, NJ 08901, USA.
Biomedicines
|June 28, 2023
概括
维生素D的充足对健康至关重要,改善免疫力,降低慢性疾病风险. 使用维生素D3补充剂和阳光照射是公共健康的成本有效策略.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D对于许多生理功能至关重要,包括新陈代谢,激素释放和免疫反应.
- 维生素D缺乏与2型糖尿病,代谢综合征,癌症,肥胖和感染等慢性疾病的风险和严重性增加有关.
- 维生素D的活性形式,酸,与维生素D受体 (VDR) 相互作用,调节1200多个基因,影响代谢和生理过程.
研究的目的:
- 为了澄清不同维生素D形式 (D3,calcifediol,calcitriol) 对各种健康状况的适当使用.
- 强调维护足够的维生素D水平对于预防慢性疾病和感染的重要性.
- 倡导用于公共卫生维生素D补充的成本有效策略.
主要方法:
- 关于维生素D代谢,功能和临床应用的现有文献的综述.
- 分析不同维生素D配方的疗效和成本效益.
- 检查维生素D不足在缓解慢性疾病和传染病中的作用.
主要成果:
- 建议使用维生素D3 (胆醇) 来纠正缺陷并提高血清25(OH) D水平.
- 二醇[25[OH]D]对血清25[OH]D的快速增加是有效的,特别是在紧急情况和重症监护中.
- 酸主要用于治疗某些疾病,如晚期功能衰竭和缺甲状腺症,而不是用于一般维生素D替代剂或感染.
结论:
- 通过维生素D3补充剂和/或阳光照射来维持足够的维生素D水平 (40ng/mL以上) 是一个具有成本效益的公共卫生策略.
- 适当的维生素D水平可以降低慢性疾病,感染和全因死亡的风险和严重程度.
- 应将适当的维生素D管理纳入常规临床护理,以降低医疗保健成本并改善整体健康结果.
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