血清阿斯素与间接胰岛素抵抗指数相关
Małgorzata Mirr1,2, Anna Braszak-Cymerman3, Aleksandra Ludziejewska4
1Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806 Poznań, Poland.
Biomedicines
|June 28, 2023
概括
肥胖个体的血清阿斯素水平显著高于肥胖个体,并且与胰岛素抵抗标志物有很强的相关性. 阿斯素显示出作为肥胖和胰岛素耐药性的可靠指标的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 生物化学 生物化学
背景情况:
- 胰岛素抵抗是导致2型糖尿病发展的关键因素.
- 亚斯素是一种新型的阿迪波金,与血糖调节有关.
- 非侵入性测试可以提供胰岛素抵抗的间接指标.
研究的目的:
- 调查血清阿斯素水平与各种胰岛素抵抗指数之间的相关性.
- 检查循环阿斯素和肥胖指数之间的关系.
主要方法:
- 该研究包括50名非糖尿病肥胖患者和50名健康志愿者.
- 收集的实验室和人体测量数据,包括血清asprosin.
- 计算的多重胰岛素抵抗指数 (例如,TyG,TyG-BMI,TG/HDLc).
主要成果:
- 肥胖患者表现出明显更高的阿斯素度 (p < 0.001).
- 阿斯素与BMI,腰围和所有测试的胰岛素抵抗指数都有正相关.
- 在阿斯素和甘油三糖指数与体重指数 (TyG-BMI) 之间发现了最强的相关性.
结论:
- 在肥胖患者中,阿斯素度会升高.
- 血清阿斯素水平与胰岛素抵抗标志物有着强烈的关联.
- 亚斯素可以被认为是肥胖和胰岛素抵抗的潜在生物标志物.
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